Polynucleotides: A New Generation of Regenerative Skin Rejuvenation

In aesthetic medicine, recent years have seen a growing shift towards an approach that is no longer based only on adding volume or smoothing individual wrinkles, but on improving skin quality from within.

The skin changes over time. It becomes thinner, drier, less elastic, slower to regenerate, less able to retain moisture, and it gradually loses its natural firmness. The visible consequences include fine lines, a tired appearance, poorer skin texture, enlarged pores, loss of radiance and slower healing after inflammation or skin damage.

One of the most interesting modern approaches to this type of rejuvenation is the use of polynucleotides — bioregenerative molecules that do not "fill" the skin, but instead stimulate its renewal, regeneration and improved function.

Within this group, the Rejuran line stands out. It is based on polynucleotides and is designed to improve skin quality, firmness, elasticity, hydration and overall skin appearance. The official Rejuran line includes products for full-face rejuvenation, reduction of under-eye concerns and treatment of scars.

Why Does Skin Age?

Skin ageing is the result of both internal and external factors. Internal factors include genetic predisposition, hormonal changes and the natural slowing down of cellular processes with age. External factors involved in skin ageing include mainly UV radiation, smoking, stress, pollution, lack of sleep and inadequate skincare.

Over time, fibroblast activity in the skin decreases. Fibroblasts are the cells that produce the key components of youthful skin: collagen, elastin and hyaluronic acid. As a result, the skin loses structure, firmness and its ability to retain moisture.

In addition, the extracellular matrix also deteriorates. This is the supportive network of the skin, containing collagen and elastin fibres, hyaluronic acid, growth signals, water and other molecules that allow the skin to regenerate normally.

When the extracellular matrix loses its organised structure, changes appear such as:

• fine lines,
• dry and dehydrated skin,
• reduced elasticity,
• thinner skin,
• tired appearance,
• poorer skin texture,
• slower healing,
• less natural radiance.

This is why modern skin rejuvenation is no longer focused only on "erasing wrinkles", but on skin renewal at the cellular and tissue level.

What Are Polynucleotides?

Polynucleotides (PN) are long chains of nucleotides — the basic building blocks of DNA and RNA. In aesthetic medicine, they are used as bioregenerative molecules that support renewal processes in the skin.

They are purified DNA fragments that, after being applied into the skin, become involved in regenerative processes. Their purpose is not to add volume, as with traditional dermal fillers, but to improve the skin microenvironment and stimulate its natural renewal.

How Do Polynucleotides Work?

Polynucleotides work on several levels. Their effect is not mechanical, but biological. This means that they do not change the skin by adding volume, but by encouraging it to function better.

1. They Stimulate Fibroblasts

Fibroblasts are key cells of connective tissue. Their role is to produce collagen, elastin and other components of the extracellular matrix, as well as to regulate all skin renewal processes.

With ageing, fibroblasts slow down and their number decreases. They produce less collagen, less elastin and fewer supportive molecules. As a result, our skin loses firmness, elasticity and its ability to regenerate.

Polynucleotides help create a more favourable environment for fibroblast activity. In this way, they may support the formation of new collagen, elastin and other structures that are important for a youthful skin appearance.

2. They Improve the Extracellular Matrix

The extracellular matrix is the foundation of high-quality skin. When it is well organised, the skin appears firmer, smoother, more hydrated and more resilient. When it is damaged, degraded or affected by inflammation, signs of ageing appear.

Polynucleotides can form a supportive structure within the tissue that binds water and supports tissue remodelling. This contributes to better hydration, elasticity and skin structure.

3. They Support Skin Hydration

Well-hydrated skin looks fresher, smoother and more radiant. With ageing, the skin's ability to retain water decreases, causing it to become drier, more tired-looking and less firm.

Polynucleotides have the ability to bind water, thereby improving tissue hydration and creating a better environment for cellular renewal. The effect is not the same as with fillers, where volume is immediately visible, but rather a gradual improvement in skin quality.

4. They Have Anti-Inflammatory and Regenerative Effects

Skin ageing is not only the result of collagen loss. It is often also associated with chronic low-grade inflammation, oxidative stress and a reduced ability to repair damage.

In the literature, polynucleotides are described as molecules that support regeneration, repair of damaged tissues, angiogenesis and anti-inflammatory processes.

5. They Improve Skin Quality Without Changing Facial Features

One of the greatest advantages of polynucleotides is that they do not alter facial features. They are not used to volumise the cheeks, lips or contours, but to improve skin texture, elasticity, hydration and overall skin quality.

They are therefore especially suitable for anyone who wants natural, fresh and gradual rejuvenation without the appearance of a "reshaped" face.

Polynucleotides Are Not Traditional Fillers

Polynucleotides are often classified as skinboosters or biostimulators, but they should not be equated with traditional dermal fillers.

Traditional fillers, most commonly based on hyaluronic acid, are mainly used for:

• replacing lost volume,
• enhancing facial contours,
• shaping the lips,
• correcting deeper wrinkles,
• lifting certain areas of the face.

Polynucleotides work differently. Their goal is to:

• improve skin quality,
• stimulate regeneration,
• improve hydration,
• reduce fine lines,
• improve texture,
• strengthen the skin barrier,
• support fibroblasts,
• improve the extracellular matrix.

If fillers are often associated with shaping, polynucleotides are associated with regeneration.

Which Concerns Are Polynucleotides Suitable For?

Polynucleotides are suitable for skin that shows signs of fatigue, ageing, dehydration or reduced regenerative capacity.

They are most commonly used for:

• fine lines,
• thin and sensitive skin,
• dehydrated skin,
• reduced elasticity,
• loss of radiance,
• tired appearance,
• enlarged pores,
• poorer skin texture,
• post-acne skin,
• scars,
• skin after inflammatory processes,
• sensitive skin around the eyes,
• early signs of ageing.

They are particularly interesting for people who do not want a pronounced change in facial features, but want better skin quality.

Rejuran: A Polynucleotide Line for Skin Regeneration

Rejuran is one of the best-known lines of polynucleotide treatments. It was developed within Korean aesthetic medicine, where a regenerative approach to improving skin quality is very well established.

Rejuran is based on polynucleotides designed to support skin renewal, improve elasticity, texture, hydration and overall skin appearance. The official Rejuran line includes three main products: Rejuran Healer, Rejuran I and Rejuran S.

Rejuran Healer

Rejuran Healer is the basic and best-known product in the Rejuran line. It is intended for full-face rejuvenation and improvement of overall skin quality.

It is especially suitable for:

• tired skin,
• dehydrated skin,
• fine lines,
• loss of elasticity,
• poorer texture,
• loss of radiance,
• early signs of ageing.

The goal of the treatment is not to change facial features, but to achieve fresher, firmer and regenerated skin.

Rejuran I

Rejuran I is intended for the area around the eyes, where the skin is thinner, more sensitive and shows signs of ageing more quickly.

It is suitable for:

• fine lines around the eyes,
• thin under-eye skin,
• tired appearance,
• reduced elasticity of the periorbital area,
• skin that is not suitable for correction with fillers.

The eye area is very delicate and requires precise indication. In some patients, concerns in this area are caused by volume loss; in others, by pigmentation, thin skin or fluid retention. This is why an individual assessment before treatment is important.

Rejuran S

Rejuran S is intended for scars and depressed areas of the skin.

It may be suitable for:

• atrophic scars,
• acne scars,
• small depressed areas,
• uneven skin texture,
• skin after inflammatory processes.

When treating scars, a realistic approach is usually necessary. The goal is not complete removal of the scar, but improvement in skin texture, quality and the visibility of irregularities. The best result is often achieved by combining different methods.

How Is a Polynucleotide Treatment Performed?

The treatment is performed on an outpatient basis using small injections into the skin. The most commonly treated areas are the face, eye area, neck, décolleté or individual scars.

Before the procedure, we assess:

• skin quality,
• elasticity,
• hydration,
• presence of fine lines,
• the eye area,
• scars or textural irregularities,
• your expectations.

Based on the consultation and examination, we choose the most suitable treatment or combination of treatments.

After treatment, small bumps at the injection sites, redness, tenderness, swelling or bruising may occur. These reactions are usually temporary and subside within a few days.

When Are the Results Visible?

With polynucleotides, results are not immediate as they are with traditional fillers. Since this is a regenerative treatment, the effect develops gradually.

The first changes patients often notice are improved hydration, freshness and skin radiance. Over time, elasticity, texture, fine lines and overall skin quality may also improve.

Because these are biological renewal processes, a series of treatments is usually recommended. The exact number of treatments depends on the initial condition of the skin, age, treatment area and treatment goals.

Who Are Polynucleotides Suitable For?

Polynucleotides are suitable for patients who want natural, gradual and regenerative skin improvement.

They are suitable for:

• first signs of ageing,
• tired skin,
• dry and dehydrated skin,
• fine lines,
• thin skin,
• the skin around the eyes,
• reduced elasticity,
• acne scars,
• uneven texture,
• patients who do not want to change their facial features,
• patients who want to improve skin quality before or after other aesthetic procedures.

When Are Polynucleotides Not Enough?

Polynucleotides improve skin quality, but they are not a solution for every aesthetic concern.

If there is significant volume loss, deep nasolabial folds, sagging tissues, pronounced skin laxity or prominent under-eye hollows caused by anatomical volume loss, a different or combined approach may be necessary.

In such cases, we may consider combining them with other methods, such as:

• hyaluronic acid fillers,
• collagen biostimulators,
• botulinum toxin,
• laser treatments,
• microneedling,
• surgical procedures in cases of more pronounced laxity.

The right choice depends on facial anatomy, skin quality, and your wishes and expectations.

Why Are Polynucleotides Different?

Polynucleotides represent a shift in aesthetics: from correcting individual wrinkles to regenerating the skin as a whole.

Their special characteristics are that they:

• do not add volume,
• do not change facial features,
• act on skin quality,
• support fibroblasts,
• improve the extracellular matrix,
• contribute to hydration,
• work gradually,
• provide a natural result.

This is especially important for patients who want a fresh, rested and natural appearance without an obvious change to the face.

Rejuran at Klinika Višnjar

At Klinika Višnjar, we understand polynucleotides as part of a modern regenerative approach to skin rejuvenation. The purpose of the treatment is not to create a different face, but to improve skin quality, elasticity, hydration, texture and regenerative capacity.

During the consultation, we assess the condition of the skin, age-related changes, the areas that concern you and your wishes. Based on this, we select the most suitable treatment from the Rejuran line or recommend a combination with other procedures.

What Can We Realistically Expect?

After a series of treatments, we can expect gradual improvement in skin quality:

• better hydration,
• a fresher appearance,
• more radiance,
• improved elasticity,
• smoother texture,
• less pronounced fine lines,
• improved quality of thin skin,
• better skin regeneration,
• a natural and gentle rejuvenating effect.

Results are individual and depend on the initial condition of the skin, age, lifestyle, genetics, sun damage and the chosen protocol.

With polynucleotides, it is important to understand that they do not provide an immediate "wow" volume effect, but rather a gradual improvement in the skin. This is precisely why they are highly suitable for anyone seeking a natural, elegant and long-term approach to rejuvenation.

Where to Start?

If you notice that your skin looks tired, thinner, less elastic, dehydrated or that it is losing its natural radiance, polynucleotides may be an excellent choice.

The first step is a professional consultation. At Klinika Višnjar, we assess skin quality, choose the most suitable product from the Rejuran line and prepare an individual treatment plan.

Modern skin rejuvenation is no longer focused only on correcting wrinkles, but on renewal, regeneration and improvement of skin quality. This is where polynucleotides and the Rejuran line have a special role.

Would you like to find out whether Rejuran is suitable for you?**

**Book a professional consultation at Klinika Višnjar.